Impact of multinutrient supplements on adult nutrient status in blood and urine in Beijing / 中华临床营养杂志

ABSTRACT

ObjectiveTo determine the impact of multinutrient supplements on adult nutrient status in Beijing, China. MethodsIn this randomized, double-blind, and placebo controlled trial, 152 healthy adults with a Recommended Food Score lower than 12 were equally and randomly divided into multinutrient supplement group and placebo group. Plasma and urine nutrient levels including vitamin A, B1, B2, B6, B12, C, folate, α- and γ-tocopherol, and carotenoids were determined before and after 8-week intervention. Acute response on vitamin C,carotenoids and tocopherols status were also determined on day 56. ResultsThree cases (5.7％) were lost to follow-up in placebo group. Compared with the placebo group, α-tocopherol [(18.23 ±0.82) vs.(14.55 ±0.73) μmol/L], β-carotene [(4.28±0.29) vs. (2.38±0.24) μmol/L], vitamin C [(42.65 ±2. 11) vs.(27.49±1.76) μmol/L], B6 [(323.51 ±15.88) vs. (69.43±10.47) nmol/L] and B12 [(1005.27 ±23.00) vs. (796.85±35.57) pmol/L] levels in plasma, B1 [(899.24±70.73) vs. (174.42±13.38)μg/g · Cr]and B2 [(3227.68 ±330.04) vs.(259.10 ±33.33) μg/g · Cr] levels in urine, and folate level in red blood cells [(720.09 ±21.33) vs. (633.17 ±28.75) nmol/L] significantly increased after 8 weeks of intervention (all P=0.0000), while plasma γ-tocopherol level significantly decreased [(2.18 ±0.13) vs. (2.87 ±0.26) μmol/L,P=0.0001]. Significant acute response on vitamin C was also observed in the multinutrient supplement group [(54.53 ±2.43) vs. (23.02 ± 1.77) μmol/L, P =0.0000]. ConclusionThis multinutrient supplement can effectively improve the nutrient status of healthy Chinese adults.