The clinical value of Aescuven forte in the treatment of the mild to moderate craniocerebral trauma in the young patients / 中国综合临床

ABSTRACT

ObjectiveTo assess the clinical efficacy and safety of Aescuven forte in the young patients with craniocerebral trauma.Methods Eighty patients diagnosed with craniocerebral trauma were randomized into treatment group and control group,in which the patients were given Aescuven forte tablets 0.3 g t.i.d for 30 days and routine treatmentsrespectively.Barthel index, Mini-Mental State Examination (MMSE)scale, Glasgow Coma Scale(GCS) and other clinical parameters were used to evaluate the efficacy by comparing their values before and 30 days after treatment.Results In the Aescuven forte treatment group, 35.0％ (14/40) and 50.0％ (20/40) of the patients showed complete response and partial response with the total response rate of 85.0％ (34/40) ,while they were 20.0％ (8/40) ,52.5％ (21/40) and 72.5％ (29/40) in the control group,respectively(x2 = 18.78 ,P ＜ 0.05) .The incidence of complications in Aescuven forte-treated group was lower than that in the control group.No severe adverse events occurred.Conclusion Aescuven forte is a safe and effective vasoactive drug for the recovery of craniocerebral trauma-caused neurological disorders and mental deterioration in young patients.