Analysis of the clinical effects of diltiazem in patients with acute left heart failure caused by hypertension and rapid atrial fibrillation / 中国医师进修杂志

ABSTRACT

ObjectiveTo explore the clinical value of diltiazem in patients with acute left heart failure caused by hypertension and rapid atrial fibrillation. MethodsNinety-nine hospitalized patients with acute left heart failure caused by hypertension and rapid atrial fibrillation were randomly divided into observation group (61 cases) and control group (38 cases). Conventional therapy was given in the two groups and diltiazem was added in observation group. Blood pressure, heart rate and respiration rate was compared.ResultsAfter treatment for 30 min and 1 h, the levels of SBP and DBP were significantly lower in observation group than those in control group (P ＜ 0.01 ). After treatment for 30 min, the rate of dyspnea disappearing,heart rate decreasing below 100 times/min, rale in lung decreasing or disappearing, quiet and sweat disappearing [44.3％ (27/61) ,42.6％ (26/61) ,44.3％ (27/61),41.0％ (25/61)] were significantly higher than those in control group [18.4％(7/38), 15.8％(6/38), 18.4％(7/38), 15.8％(6/38)] (P ＜ 0.01 ). After treatment for 1 h, the levels of above mentioned index were significantly higher than those in control group (P ＜ 0.01 ). ConclusionDiltiazem has exact effect in the treatment of acute left heart failure caused by hypertension and rapid atrial fibrillation, and is valuable in clinic.