Serum sialic acids in the diagnosis of digestive tract tumor / 中华健康管理学杂志
Chinese Journal of Health Management
;
(6): 302-305, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-422294
ABSTRACT
Objective To investigate serum levels of sialic acids(SA)vs carcino-embryonic antigen(CEA)for the diagnosis of digestive tract cancer.Methods Sixty healthy adults,100 patients with malignant digestive tract tumor and those undergoing radical digestive tract tumor surgery were enrolled in this case-control study.Serum SA level was tested.Serum CEA level was measured by electrochemical luminescence.Sensitivity and specificity of SAvs CEA were calculated.Receiver operating characteristic (ROC)curve and area under the curve(ROC-AUC)were used to evaluate the diagnostic value of SA.Results Serum level of SA of patients with digestive malignant tumors was much higher than the normal controls(P <0.01),although serum SA of patients undergoing tumor resection showed no difference with the normal controls(P > 0.05).There was significant difference in SA level between the patients who received surgical therapy or not.The sensitivity and specificity of SA in diagnosing digestive tract cancer was 55.00% and 93.3%,respectively.The false positive rate was 6.7% in normal subjects.Conclusion Serum SA or CEA testing may be equally useful in the screening,diagnosis,outcome assessment and followup study of digestive tract cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Health Management
Year:
2011
Type:
Article
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