Observation on High-frequency oscillatory ventilation in the treatment of severe neonatal respiratory distress syndrome / 中国医师杂志

ABSTRACT

Objective To evaluate the effectives of high-frequency oscillatory ventilation (HFOV)in the treatment of severe NRDS.Methods The severe NRDS who failed to response to conventional mechanical ventilation (CMV) were changed to HFOV treatment.Ventilator parameters and blood gas analysis were compared before and after treatment.Results Among thirty patients,19 cases were significantly improved and 11 cases were failed,the success rate was 63％.Nineteen patients with HFOV,the main ventilator parameters and blood gas results such as FiO2 ( 0 h0.87 ± 0.09 vs 3 h0.67 ± 0.10,6 h0.54 ±0.08,12h0.44 ±0.08),MAP[0 h(14.47 ±1.17) mbar vs 3 h(13.79 ± 1.03) mbar,6 h(13.26 ±1.05) mbar,12 h( 12.37 ±0.83) mbar],f[0 h(7.26 ±0.56) Hz vs 3 h(7.89 ±0.57) Hz,6 h(8.42±0.51 ) Hz,12 h(9.26 ±0.45) Hz] and PaCO2 [0 h(9.69 ±0.86) kPa vs 3 h(6.00 ±0.55) kPa,6 h(5.62 ± 1.03)kPa,12 h(5.47 ±0.55)kPa] were decreased while pH(0 h7.21 ±0.06 vs 3 h7.35 ±0.07,6 h7.39 ±0.07,12 h7.40 ±0.06) and PaO2[0 h(5.46 ±0.82)kPa vs 3 h(7.92 ± 1.13)kPa,6 h(9.25 ± 0.99)kPa,12 h(9.20 ± 0.96)kPa] were significantly increased compared with before treatment ( P ＜ 0.05).Conclusions The patients of severe NRDS who failed to response to CMV were treated with HFOV,some patients received a significant effect with HFOV treatment.