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Comparative clinical effectiveness of donepezil versus huperzine in elderly patients with mild cognitive impairment / 中华老年医学杂志
Chinese Journal of Geriatrics ; (12): 808-811, 2011.
Article in Chinese | WPRIM | ID: wpr-422541
ABSTRACT
Objective To assess the effectiveness of donepezil versus huperzine in the treatment of elderly patients with mild cognitive impairment (MCI).Methods Total 122 elderly patients with MCI were divided into two groupsdonepezil treatment (5.0 mg once daily) (n=71) and huperzine treatment group (0.1 mg twice daily) (n=51).All the patients were followed up for 24 weeks.Before and 12 weeks,24 weeks after drug treatment,the cognitive functions were evaluated,including MMSE,MOCA,ADAS-cog,CDR,GDS,ADL,HIS and HAMD.Results There was no significant difference in age,sex,education time and neuropsychology rating scales between the groups before drug use.As compared with the score before drug use,the donepezil group showed a significant increase in MMSE after 12-weeks (t=4.47) or 24-weeks (t=6.16) (P<0.01),a decrease in the score of ADAS-cog after 12-weeks (t=2.33,P<0.05) or 24-weeks( t=3.68,P<0.05),and an increase in the score of MOCA after 24-weeks drug use (t=2.56,P<0.05).The huperzine group showed significant improvement in MMSE after 24-weeks drug use (t=2.80,P<0.05),but there was no difference in other time points or in the score of MOCA and ADAS-cog as compared with the score before drug use.After 24 weeks' treatment,the donepezil group had higher MMSE (t=2.01,P<0.05) and lower ADAS-cog (t=2.09,P<0.05) scores than the huperzine group.30 patients (total effective rate was 42.3 %) and 9 patients (total effective rate was 17.6 % ) became improved in donepezil and huperzine group,respectively,with significant difference (x2 =8.26,P<0.01 ).There were 5 cases in the donepezil group and 3 cases in the huperzine group getting slight side-effects which disappeared by continuing to take drugs or by adjusting drug taking time.Conclusions Donepezil and huperzine as the cholinesterase inhibitors are effective and safe,and the efficacy of donepezil is faster and better in treating elderly patients with MCI.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Geriatrics Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Geriatrics Year: 2011 Type: Article