The Relationship between Microalbuminuria and Coronary Artery Stenosis or Inflammatory Markers in Patients with Angina Pectoris
Korean Circulation Journal
;
: 49-54, 2005.
Article
in Korean
| WPRIM
| ID: wpr-42260
ABSTRACT
BACKGROUND AND OBJECTIVES:
Microalbuminuria is associated with increased cardiovascular risk factors and mortality. The aims of this study were to clarify the relationship between the spot urine albumin-creatinine ratio (ACR) and coronary artery stenosis on diagnostic coronary angiograms and to investigate its association with inflammatory markers. SUBJECTS ANDMETHODS:
One hundred thirteen consecutive patients, who underwent a diagnostic coronary angiogram, between April 2004 and July 2004, were divided into two groups group I (n=89, 58+/-1 2 years, 6 1 male, no microalbuminuria) and group II (n=24, 65+/-10 years, 14 male, microalbuminuria). Microalbuminuria was diagnosed when the ACR was between 30 and 300 mg/g.cr.RESULTS:
The mean age was higher in group II than group I (58+/-1 2 vs. 65+/-1 0 years, p=0.013), and group II also showed higher levels of white blood cell (7.0+/-2.4 vs. 9.5+/-4.1 x 103/mm3, p=0.009), monocyte (0.4+/-0.2 vs. 0.5+/-0.2 x 103/mm3, p=0.039), homocysteine (8.8+/-3.5 vs. 10.8+/-4.1 micro mol/L, p=0.02) and fasting plasma glucose (126.1+/-33.6 vs. 183.7+/-75.3mg/dL, p=0.001), and more frequent higher value of high sensitivity C-reactive protein (>0.5mg/dL) (16.9 vs. 66.7%, p<0.001 ) compared with those of group I. There was a correlation between the ACR and all the inflammatory markers tested. Significant coronary lesions, requiring percutaneous coronary intervention, were more frequently detected in group II than in group I (50.6 vs. 75%, p=0.032).CONCLUSION:
The ACR was associated with significant coronary artery disease and the inflammatory markers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood Glucose
/
Coronary Artery Disease
/
C-Reactive Protein
/
Monocytes
/
Risk Factors
/
Mortality
/
Fasting
/
Coronary Disease
/
Coronary Vessels
/
Coronary Stenosis
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Language:
Korean
Journal:
Korean Circulation Journal
Year:
2005
Type:
Article
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