Transplantation of bone marrow mesenchymal stem cells in rat model of Tourette syndrome / 中华行为医学与脑科学杂志
Chinese Journal of Behavioral Medicine and Brain Science
; (12): 990-992, 2011.
Article
in Zh
| WPRIM
| ID: wpr-422870
Responsible library:
WPRO
ABSTRACT
ObjectiveTo investigate the effect of mescenchymal stem cell (MSC) transplantation on Tourette syndrome(TS)model rats.MethodsStereotypies can be successfully induced in rats by intrastriatal microinfusion of TS sera.MSC suspension was bilaterally injected into the striatum.Survival and differentiation of transplanted MSC were tested through immunohistochemical analyses.ResultsFlow cytometry results demonstrated that the cells strongly expressed CD29(95.2% ),CD105(97.2% ),CD44(96.3% ) and CD106 (94.1%).TS rats with MSC grafts exhibited significantly decreased stereotypic behaviors at 10 and 14 days(95.5 ±6.6,73.1 ± 6.5 vs.114.1 ± 6.0,108.0 ± 6.4).Immunohistochemistry analyses revealed survival of transplanted MSC and differentiation into neurons and astrocytes in the rat brain.ConclusionIntrastriatal transplantation of human MSC can provide therapeutic potential for TS.
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WPRIM
Language:
Zh
Journal:
Chinese Journal of Behavioral Medicine and Brain Science
Year:
2011
Type:
Article