Factors affecting hematologic recovery and infection in high-dose chemotherapy and autologous stem cell transplantation in patients with high-risk solid tumor / 소아과
Korean Journal of Pediatrics
;
: 1079-1085, 2006.
Article
in Korean
| WPRIM
| ID: wpr-42312
ABSTRACT
PURPOSE:
The purpose of this study was to evaluate factors affecting hematologic recovery and infection in high-dose chemotherapy(HDCT) and autologous stem cell transplantation(ASCT) in patients with high-risk solid tumor.METHODS:
From January 2004 to December 2005, 72 HDCTs and ASCTs were applied to children with high-risk solid tumor at Samsung Medical Center. Medical records of these 72 HDCTs and ASCTs were retrospectively analyzed.RESULTS:
The single most powerful predictor of neutrophil and platelet recovery was the number of transplanted CD34+ cells. The duration of high fever was significantly longer in young patients, in patients treated with total body irradiation and/or thiotepa, and in patients transplanted with lower CD34+ cell dose(1x10(6)/kg per transplantation. Therefore, it is important not to defer the appropriate time for HDCT for an additional collection of hematopoietic stem cells if the number of collected CD34+ cells is >1x10(6)/kg per transplantation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stem Cells
/
Blood Platelets
/
Hematopoietic Stem Cells
/
Medical Records
/
Retrospective Studies
/
Whole-Body Irradiation
/
Thiotepa
/
Stem Cell Transplantation
/
Drug Therapy
/
Fever
Type of study:
Etiology study
/
Observational study
/
Prognostic study
Limits:
Child
/
Humans
Language:
Korean
Journal:
Korean Journal of Pediatrics
Year:
2006
Type:
Article
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