Preparation and mechanism of anticoagulatent biomedical polymer materials with blood compatibility / 中国组织工程研究

ABSTRACT

BACKGROUND: Biomedical materials contact internal environment of human body, and sometimes are implanted into organism. Therefore, they should have biocompatibility, chemical stability, suitable physical mechanical function and simple processing and molding, but no toxicity.OBJECTIVE: To investigate the preparation of biomedical polymer anticoagulant materials in the aspects of bioinert material, biological active surface, albumin structure and application in anticoagulation.METHODS: A computer-based online search of PubMed and Wanfang database was performed for articles related to preparation of biomedical polymer anticoagulant materials published between 1969 and 2010.RESULTS AND CONCLUSION: Currently preparation of anticoagulant materials commonly utilizes bioinert surface or bioactive surface alone, which has obtained good effects, but the biocompatibility, such as blood compatibility, cannot be retained for a long period of time. The combination of bioinert surface and bioactive surface plus albumin, natural constitutions in human blood may be the trend of anticoagulant materials development. Polyethylene glycol with high bioinert property in combination with albumin recognition factor cibacron blue with high bioactivity can be used to prepare active modifier, which is used to modify polyurethane.