Endocytosis and exocytosis of gold nanochain attaching Hep-2 cells of human laryngeal carcinoma / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
;
(53): 1363-1366, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-423955
ABSTRACT
BACKGROUND:
The gold nanoparticles have a killing effect on tumor cells.OBJECTIVE:
To investigate the influence of gold nanochain on Hep-2 cells proliferation of human laryngeal carcinoma.METHODS:
The gold nanochain was prepared by a glucose synthesis method and added into the culture cells with different concentrations (10%, 25%, 50%, 75%, 95%) to test the influence on proliferation of in vitro cultured Hep-2 cells. The endocytosis and exocytosis of transmembrane when gold nanochain attached to Hep-2 cells were observed by electron microscopy.RESULTS ANDCONCLUSION:
The gold chain at high concentrations (75%, 95%) exhibited inhibitory effects on the proliferation of Hep-2 cells, but the influence was not increased with increasing concentration, belonging to a range of non-toxic. Gold nanchain can enter into Hep-2 cells after 8 hours of co-culture and leave cells after 48 hours, indicating gold nanoparticles chain can enter and leave Hep-2 freely.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Tissue Engineering Research
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS