Study on abnormal expression of transforming growth factor-β1 in maternal blood and placenta of patients with fetal growth restriction / 中国医师杂志
Journal of Chinese Physician
;
(12): 938-940, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-424148
ABSTRACT
Objective To find out the relationship between fetal growth restriction (FGR) and transforming growth factor -β1 (TGF-β1). Methods The levels of TGF-β1 in maternal serum and placental tissue of FGR were detected with using ELISA and immunohistochemistry technique, and it was compared with those of normal term pregnancy. Results The levels of TGF-β1 in maternal serum of FGR group were significantly higher than those of normal term pregnancy (76. 5 ± 33. 4 VS 47.6 ± 24. 2, t' = 4. 65, P <0. 05). As for the intensity of the immunohistochemistry signal, TGF-β1 in syncytiotrophoblastic cells of FGR was markedly higher than that of control group (81.82% vs 5.83%, P <0. 01). Conclusions The levels of TGF-β1 are closely related with FGR.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Chinese Physician
Year:
2011
Type:
Article
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