Effects of high glucose on the expression of angiotensin-converting enzyme/angiotensin converting enzyme 2 in human proximal tubular cells / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 680-682, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-424335
ABSTRACT
HK-2 cells cultured in vitro were divided into three groups normal glucose group ( NG ), high glucose group( HG), and mannitol group(MG). The expression of angiotensin-converting enzyme( ACE ) and ACE2 mRNA in HK-2 cells was detected. The concentration of angiotensin Ⅱ ( Ang Ⅱ ) in the culture medium was detected. The mRNA and protein expression of ACE and ACE2 existed in normal cultured HK-2 ( NG group ). In comparison with NG group, the mRNA and protein expressions of ACE in HG group increased significantly ( P<0. 01 ), and the expression of ACE2 mRNA decreased significantly( P<0. 01 ). The level of Ang Ⅱ in HG group was significantly higher than in NG group( P<0. 05 ). The result show that high glucose may induce ACE expression and inhibit ACE2 expression, then promote synthesis of Ang Ⅱ in proximal tubular cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
2011
Type:
Article
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