Expression of tumor necrosis factor-α in ovarian carcinoma ascites and its meaning / 国际生物医学工程杂志

ABSTRACT

ObjectiveTo investigate the relationship of ovarian cancer and the ascites levels of TNF-α,and to determine the value of elevated TNF-α ascites level on discriminating the feature of ascites.MethodsAscites levels of TNF-α of 59 specimens of epithelial ovarian tumor,9 specimens of peritoneal primary serous papillary carcinoma (PPSPC) and 6 specimens of endometriosis cyst were detected via ELISA.ResultsAscites levels of TNF-α of patients with EOC,PPSPC,BOT were significantly higher than those with BET and EM,and they were related to the clinical stage,tissue differentiation,lymph node metastasis and volume of ascites.ConclusionAscites levels of TNF-α have the high sensitivity and specificity for diagnosis of ovarian cancer.It might be the tumor marker of ovarian cancer.