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Long-term results and prognostic factors after anatomical hepatectomy for hepatocellular carcinoma: a report of 90 patients / 中华肝胆外科杂志
Chinese Journal of Hepatobiliary Surgery ; (12): 110-114, 2012.
Article in Chinese | WPRIM | ID: wpr-424892
ABSTRACT
Objective To investigate the safety and long-term therapeutic results of anatomical hepatectomy for hepatocellular carcinoma (HCC).Methods 90 patients underwent anatomical hepatectomy from January,2003 to January,2010.The tumor size was ≤5 cm in 38 patients,and >5 cm in 52 patients.The tumor number was a single lesion in 58 patients,and multiple lesions in 32 patients.Cirrhosis was present in 46 patients (55.42%); cancer embolus was present in 34 patients (37.78%).There were 64 patients in Child-Pugh A and 26 patients in B.The operating time,blood loss and blood transfusion were recorded and analyzed.Complications and liver function were monitored after surgery.The Kaplan-Meier method was used to calculate the survival rates.Log-rank test was used to analyze factors associating with postoperative recurrence.Independent factors influencing tumor-free survival and overall survival were analyzed by Cox-model logistic regression.Result There was no perioperative death.The incidence of complications was 31.1% (28/90).The recurrence rate was 51.1% (46/90).The 1-,3-,5 year tumor-free survivals were 92.2%,67.3% and 49.7%%00,respectively.Positive resection margin and satellite nodule were independent factors for recurrence (RR19.22,95 % confidence interval 5.85~63.17).The 1-,3-,5-year overall survivals were 94.4%,80.0% and 60.0%,respectively.Positive resection margin and TNM were independent factors for overall survival (RR 2.013,95% confidence interval 1.28~3.17).Conclusions Anatomical hepatectomy was a safe and efficacious procedure to treat HCC.Positive resection margin and TNM were independent factors associated with overall survival.Anatomical hepatectomy had the advantages in ensuring a lower rate of negative resection margin.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Hepatobiliary Surgery Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Hepatobiliary Surgery Year: 2012 Type: Article