Application of proteomics in research for gastrointestinal tumors / 国际外科学杂志

ABSTRACT

Proteomics is a technology to study all the proteins encoded by gene.It has become a useful tool for analyzing the expression changes of proteins,and has been widely used in research of gastrointestinal tumors in recent years.Through kinds of techniques such as two-dimensional gel electrophoresis,some differentially expressed proteins correlated with patients prognosis were found,which may served as the possible biomarkers of gastroin testinal tumors in future.It helped to find some certain proteins related to tumor cell nutritional intake,cell metabolism,cell adhesion,cell migration and cytoskeleton remodeling which may play the important roles in development of gastrointestinal tumor.It also helped to explain the drug resistance mechacism of chemotherapy and molecular targeted theraphy for gastrointestinal tumors.Proteomics technology plays an increasingly important role in the basic research and clinical services for gastrointestinal tumors.