Observation on the effect of entecavir combined with oxymatrine in the treatment of patients with hepatitis B / 中国基层医药

ABSTRACT

Objective To observe the clinical effect of entecavir combined with oxymatrine in the treatment of patients with hepatitis B.Methods 74 patients with hepatitis B were randomly divided into two groups.The treatment group(40 cases) were given entecavir 0.5mg daily,oxymatine 600mg,intravenous daily.The control group (34 cases) were given entercavir 0.5mg daily.The HBeAg and Anti-HBe negative conversion rates,the HBV-DNA negative conversion rate and the ALT normalization rate after 1,3,6,9,12 months in treatment period and 6,12months in follow-up period were observed.Results After 1,3,6,9,12 months in treatment period and 6,12 months in follow-up period,the HBeAg and Anti-HBe negative conversion rates of the treatment group was 32.5％,45.0％,60.0％,60.0％,62.5％,62.5％ and 62.5％,while that of the control group was 5.9％,5.9％,8.8％,11.8％,11.8％,11.8％ and 11.8％,there was significant difference between them( x2 =5.46,12.83,25.22,21.68,24.79,24.79,24.79,all P ＜0.05).The ALT normalization rate of the treatment groups was 45.0％,67.5％,87.5％,90.0％,90.0％,90.0％ and 90.0％,while that of the control group was 20.6％,32.4％,41.2％,50.0％,52.9％,52.9％ and 52.9％,there was significantly difference between them ( x2 =4.60,10.36,20.67,14.47,12.08,12.08,12.08,all P ＜ 0.05 ).Conclusion Entecavir combined with oxymatrine in the treatment of patients with hepatitis B had a synergistic antiviral effect,high security and simple treatment.It was worthy to promote.