Gene mutations and the phenotype of BCR/ABL-negative myeloproliferative neoplasms / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 307-310, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-425286
ABSTRACT
Janus kinase 2,myeloproliferative leukemia virus and tet encogene family member2 mutations affect a variety of cytokines signal transduction pathway in BCR/ABL-negative myeloproliferative neoplasms (MPN). In the influence of mutation load,co-mutation and genetic susceptibility,these mutations can induce different MPN phenotypes,and affect the characteristics of patients,the distribution of peripheral blood cells and prognosis. But how these mutations contribute to disease initiation,development,and transformation needs further reseach.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Journal of International Oncology
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS