Research for early growth response gene-1 in ischemia-reperfusion injury / 国际外科学杂志
International Journal of Surgery
; (12): 267-270, 2012.
Article
in Zh
| WPRIM
| ID: wpr-425300
Responsible library:
WPRO
ABSTRACT
Early growth response gene-1 is an immediate early response gene,a transcription factor which includ three zinc finger-like domains.Recentl studies demonstrate that early growth response gene-1 is involved in regulating cell cycle,proliferation and differentiation,and plays a critical role in injuring and repairing.Early growth response gene- 1 induces Target genes,and promotes extracellular environmental signal( such as oxygen deficit,oxidative stress,mechanical injury and cytokine)link with the complex biological responses.Intensive study to early growth respnse gene-1 will contribute to further illustrate the mechanism of the ischemia-reperfusion injury.This article summarizes from protein structure,signal transduction,biological functions and the relationship with ischemia- reperfusion injury.
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
International Journal of Surgery
Year:
2012
Type:
Article