Meta-analysis for the curative effects of simvastatin combined with low molecular weight heparin in patient with unstable angina / 中国基层医药

ABSTRACT

Objective To assess the curative effects of simvastatin combine with low molecular weight heparin in patient with unstable angina.Methods The papers from China Academic Journal ( CNKI),Chongqing VIP (VIP),PubMed database were retrieved by computer,15 randomized controlled trials( 1206 patients) were included for Meta-analysis.ResultsThe overall efficiency of the two groups were compared by Fixed effects modelx2 =2.62,Consolidated RR =1.30 (95％ CI1.23 ～ 1.38 ) ; the number of attacks after treatment of the two groups were compared by random effects modelx2 =1231.87,WMD =- 2.68 ( - 5.82,0.5 ) ; the duration time of attacks after treatment in both groups were compared by random effects modelx2 =1231.87,weighted mean difference =-2.68(-5.82,0.5).Conclusion Simvastatin combine with low molecular weight heparin could improve the overall efficiency on patient with unstable angina,and could not reduce the number of attacks after treatment,but could reduce the duration time of attacks after the treatment.