Influence of mannitol used in early stage of intracranial hematoma / 中国基层医药

ABSTRACT

ObjectiveTo study the influence of mannitol used in eraly stage of intracranial hematoma.Methods178 cases diagnosed intracranial hematoma were divided into two groups according to the treatment.After admission,all patients were detected by CT.On the basis of the routine treatment,the treatment group(88 cases) were given mannitol within 6h after bleeding,while the control group were given nothing.To observe the change in hematoma size,GCS score and the quality of life 30d after treatment.ResultsThe experiment group's average bleeding loss was(27.6±5.7)ml,while the control group's average bleeding loss was(23.1 ±4.8)ml,the proportion of patient of treatment groups whose hematoma increased was significantly greater than the control group(P ＜0.05).At the aspect of GCS score,the experiment group was (5.0 ± 1.5 ),while the control group was ( 9.5 ± 1.5 ),the average score of treatment group was significantly lower than the control group(P ＜ 0.05).30d after treatment,14 cases of experiment group dead,the mortality rate was 15.91％,while the control group's motality rate was 7.78％.The mortality rate of treatment group was significantly higher than the control group(P ＜ 0.05).ConclusionMannitol used in early stage of intracranial hematoma promotes the growth of intracranial hematoma and increases the mortality.The patients with intracranial hematoma should avoid the use of manntol in early stage.