Clinical value of respiratory mechanics in neonates with respiratory distress syndrome / 中国小儿急救医学

ABSTRACT

ObjectiveTo explore the clinical value of respiratory mechanics in neonates with neonatal respiratory distress syndrome (NRDS).MethodsAccording to prognosis,55 newborns with NRDS who had been treated with pulmonary surfactant in our hospital from Jan 2006 to Dec 2008 were divided into 2 groups44 newborns in survival group and 11 newborns in death group.The dynamical changes of compliance of the respiratory system (Crs),respiratory index (RI) and PA-a O2 were measured during mechanical ventilation.ResultsAt 6 h after mechanic ventilation,there were significant differences in Crs,PA-a O2,OI and RI between the survival group and the death group (t=6.871,-6.450,-10.316,-8.815,P＜0.05 ).In the survival group,RI,PA-aO2 and OI decreased with the time of ventilation,and there were significant differences among the different time point ( F=215.56,147.85,384.64,P＜0.05).In thesurvival group,Crs increased with the time of ventilation,and there were significant differences among the different time point ( F=292,P＜0.05).In the death group,RI,PA-aO2 and OI increased respectively just before dying than at 6 h after mechanic ventilation (t=-5.699,-5.578,-6.924,P＜0.05 ).In the death group,Crs decreased respectively just before dying than at 6 h after mechanic ventilation (t=11.767,P＜0.05 ).Crs was negative correlated with OI,RI and PA-aO2 (r=-0.813,-0.800,-0.859,P＜0.05 ).ConclusionMonitoring in NRDS children's dynamic changes of Crs,RI,OI,PA-a O2 can help observing effect of treatment,guiding ventilator treatment,grasping the opportunity and assessing the prognosis offline in NRDS.