No Effect of Serotoninergic Gene Variants on Response to Interpersonal Counseling and Antidepressants in Major Depression
Psychiatry Investigation
;
: 180-189, 2013.
Article
in English
| WPRIM
| ID: wpr-42589
ABSTRACT
OBJECTIVE:
Gene variants within the serotonin pathway have been associated with major depressive disorder (MDD) treatment outcomes, however a possible different modulation on pharmacological or psychological treatments has never been investigated.METHODS:
One hundred sixty MDD patients were partially randomized to either inter-personal counseling (IPC) or antidepressants. The primary outcome was remission at week 8. Five serotonergic polymorphisms were investigated (COMT rs4680, HTR1A rs6295, HTR2A rs2224721, HTR2A rs7997012 and SLC6A4 rs421417).RESULTS:
IPC (n=43) and antidepressant (n=117) treated patients did not show any difference in remission rates at week 8 (corrected for baseline severity, age and center). None of the studied gene variants impacted on response and remission rates at week 8 neither in the IPC nor in the antidepressant group. An analysis of the whole sample showed a trend of association between rs7997012 AA genotype and a better treatment outcome.CONCLUSION:
Our study confirms that IPC is an effective psychological intervention comparable to antidepressants in mild-moderate MDD. Polymorphisms related to the serotonin system did not exert a major effect on clinical outcomes in none of the treatment groups.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Psychotherapy
/
Serotonin
/
Counseling
/
Receptor, Serotonin, 5-HT1A
/
Receptor, Serotonin, 5-HT2A
/
Depression
/
Depressive Disorder, Major
/
Serotonin Plasma Membrane Transport Proteins
/
Genotype
/
Antidepressive Agents
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
English
Journal:
Psychiatry Investigation
Year:
2013
Type:
Article
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