Research progress of additives for improving therapeutic peptides and proteins stability in PLGA microspheres / 国际生物医学工程杂志
International Journal of Biomedical Engineering
;
(6): 185-188, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-425899
ABSTRACT
Microspheres made of poly-lactic-co-glycolic acid (PLGA) have been frequently proposed as drug delivery systems.A very significant challenge in the development of controlled PLGA releasing systems is the instability of drugs especially therapeutic peptides and proteins.Additional approaches,particularly the use of additives,are needed to optimize PLGA delivery of drugs.This article reviews the effects of additives,especially the effects of stabilizing protein during the preparation of PLGA microsphere and the sustained drug releasing processes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Biomedical Engineering
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS