Hepatocyte growth factor and its receptor in multiple myeloma / 国际肿瘤学杂志

ABSTRACT

Hepatocyte growth factor ( HGF),a multifunctional cytokine,plays a biological role through acting on the cell surface transmembrane receptor c-Met.The growth,invasion and metastasis of many tumors are associated with the abnormalities of HGF-c-Met signaling pathway.Studies found that HGF and its receptor c-Met have close relations with the occurrence,metastasis,invasion and prognosis of multiple myeloma.