The role of amplified in breast family and their research mechanisms in ovarian cancer / 国际肿瘤学杂志

ABSTRACT

The genes amplified in breast cancer family,as the novel defined hormone receptor co-activators,of which the key number is amplified in breast(AIB) 1,is critical to the transcriptional activation function of nuclear hormone receptors.The abnormal expression of protein is related to the tumorigenesis and development of many tumors.Recently,emerging evidence suggests that the member of AIB family expresses abnormally and amplifies in ovarian tumors.Collectively,these results suggest that the AIB family is involved in the carcinogenesis and the development of ovarian cancers.Further research is required to explore the mechanism and significance as well as to determine the role of AIB family in ovarian cancers,which will potentially leading to a new prognostic marker and new therapeutic targets.