Autophagy and invasion and metastasis in malignant tumor / 国际肿瘤学杂志

ABSTRACT

In the complex set of biological processes that a particular malignancy to metastasize,tumor cells must adapt to different survival pressures.As an important cell-physiologic response that under regulation of many genes and their expressions,autophagy not only can be strongly induced to adapt to metabolic stresses and microenvironmental changes,but also involved in the process of epithelial-mesenchymal transition ( EMT),restcting inflammation,resisting anoikis,maintaining dormancy in the metastatic process.