Clinical study of three-dimensional conformal radiotherapy combined with XELOX program chemotherapy for postoperative abdominal lymph nodes metastasis of gastric cancer / 中国医师进修杂志

ABSTRACT

Objective To investigate the clinical effect of three-dimensional conformal radiotherapy combined with XELOX program chemotherapy for postoperative abdominal lymph nodes metastasis of gastric cancer.Methods Seventy-one patients with postoperative abdominal lymph nodes metastasis were divided by random digits table method into treatment group (36 cases) who treated with three-dimensional confomal radiotherapy combined with XELOX program chemotherapy and control group (35 cases) who treated with XELOX program chemotherapy.The short-term efficacy,the control rate of symptoms,the long-term survival rate and adverse reaction were observed in two groups.Results The complete remission rate and objective response rate in treatment group and control group were 36.1％(13/36),20.0％(7/35) and 77.8％(28/36),60.0％(21/35),respectively,there were significant differences between two groups (P ＜0.05).The overall control rate of abdominal pain,bloating,low back pain in treatment group was 80.6％ (29/36),significantly higher than that in control group [51.4％(18/35) ](P ＜ 0.01 ).Followed up for 2 years,the followed up rate waa 97.2％(69/71 ).The 1,2-year survival rates in treatment group and control group were 42.9％ (15/35),22.9％(8/35) and 20.6％(7/34),5.9％(2/34),respectively,and the median survival time was 11.6 months and 4.9 months,there were significant differences between two groups(P ＜ 0.01 ).The incicdence rates of bone marrow suppression and gastrointestinal tract in treatment group were obviously higher than those in controlgroup (P ＜ 0.01 ),and the symptoms all were improved after treatment.Conclusions Postoperative lymph nodes metastasis of gastric cancer is sensitive to concurrent chemoradiotherapy.Concurrent chemoradiotherapy can improve the short-term efficacy and prolong survival time,but the adverse reactions increase.