The advances on prophylaxis in children with haemophilia / 国际儿科学杂志

ABSTRACT

Haemophilia,including haemophilia A and haemophilia B,is a hemorrhagic hereditary disease in children.Long-time bleeding may lead to arthropathy,while on-demand therapy couldn't reverse the damage of the affected joint.Therefore,prophylaxis has attracted much attention.The main purpose of prophylaxis is to prevent the hemarthroses and arthropathy and to improve the life quality as well.Recently,several studies confirm the efficacy of prophylaxis.Failure of prophylaxis may relate to several barriers,such as the correct regimen,the development of inhibitor and the exorbitant cost.