The genetic polymorphisms of mannose binding lectin and Kawasaki disease / 国际儿科学杂志

ABSTRACT

Kawasaki disease(KD) is a common autoimmune disease in children.KD is characterized as a systemic artcriolar inflammatory,but its pathogenesis is still not clear.In recent years,many studies have shown KD is associated with the polymorphisms of multiple genetic fragments.The relationship between mannose binding lectin(MBL) gene and KD has attracted much attention.This review introduces the construction and function of MBL briefly,and focuses on the relationship between the genetic polymorphisms of MBL and susceptibility,cardiovascular damage of KD.