Clinical significance of lndoleamine 2,3-dioxygenase (IDO) and B7-H1 expressions in pancreatic carcinoma patients undergone pancreatoduodenectomy / 中华肝胆外科杂志
Chinese Journal of Hepatobiliary Surgery
;
(12): 503-507, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-426760
ABSTRACT
ObjectiveTo analyze the relationship between expressions of Indoleamine 2,3-dioxygenase (IDO) and B7-H1 with clinico-pathological features and their prognostic significance in pancreatic cancer (PC).Method95 patients who underwent radical pancreaticoduodenectomy for PC were studied.The IDO and B7-H1 expressions in tissue specimens were determined by immunohistochemistry.ResultsIDO and B7-H1 expressions were higher in pancreatic carcinoma tissues than in normal pancreatic tissues (P<0.05).IDO and B7-H1 expressions positively and significantly correlated with pathological grades and tumour-node-metastasis (TNM) stages (P<0.05).They were prognostic of poor cancer-specific survival.After adjusting by the Cox proportional hazards regression models (P<0.05),only a combined IDO/B7-H1 expression served as an independent prognostic marker.ConclusionsIDO and B7-H1 were expressed in PC,and they were important markers for malignant progression of PC.A combined IDO/B7-H1 expression served as an independent prognostic marker for PC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Hepatobiliary Surgery
Year:
2012
Type:
Article
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