Your browser doesn't support javascript.
loading
The association between polymorphism of HLA-DRB1 allele and systemic sclerosis and renal damage in Han Chinese of Henan Province / 中华风湿病学杂志
Chinese Journal of Rheumatology ; (12): 446-452, 2012.
Article in Zh | WPRIM | ID: wpr-427339
Responsible library: WPRO
ABSTRACT
Objective To investigate the association between polymorphism of HLA-DRB1 allele and systemic sclerosis (SSc) and scleroderma-associated renal damage in Han Chinese of Henan Province.Methods Eighty-one SSc patients and 90 normal controls were recruited in this study,among them 59 patients had renal damage (SRD).The genotyping was carried out by nest PCR-SBT and gene clone.Comparisons between groups were performed with x2 test or exact probabilities.Multivariable Logistic regression was used to evaluate the association between prevalence of SSc or SRD and the possible relevant alleles.Results Thirty-three HLA-DRB1 alleles were discovered from the specimens,including 27 in SSc specimens,and 22 in SRD.Among them,the allele frequencies of HLA-DRB1 * 040501 (8.64%), * 110101 (11.11%), * 150201(8.02%) were higher in SSc patients than those of the controls (1.67%,4.44%,2.22% respectively).After adjusted for other factors,HLA-DRBl * 040501 (P=0.010,OR =5.839,95%CI:1.518-22.460)、* 110101(P=0.019,OR=3.060,95%CI:1.204-7.772)、* 150201(P=0.010,OR=4.780,95%CI:1.444-15.821 )were identified as independent risk factors for SSc.And the allele frequencies of HLA-DRB1*040501 (9.32%),* 150201 (7.63%) were higher in SRD patients than those of the controls (1.67%,2.22% respectively).After adjusted for other factors,HLA-DRB1 * 040501 (P=0.008,OR=6.363,95%CI:1.614-25.087) and * 150201 (P=0.030,OR =4.043,95 %CI:1.147-14.243 ) were identified as independent risk factors for SRD.Conclusion Our data suggest that HLA-DRB1 * 040501,* 110101,* 150201 may be susceptible genes for SSc and the HLA-DRB1 * 040501,* 150201 may be susceptible genes for SRD in Han Chinese of Henan Province.
Key words
Full text: 1 Index: WPRIM Type of study: Prognostic_studies / Risk_factors_studies Language: Zh Journal: Chinese Journal of Rheumatology Year: 2012 Type: Article
Full text: 1 Index: WPRIM Type of study: Prognostic_studies / Risk_factors_studies Language: Zh Journal: Chinese Journal of Rheumatology Year: 2012 Type: Article