Molecular mechanism of flavonoids for preventing radiation-induced lung injury / 国际肿瘤学杂志

ABSTRACT

Radiation-induced lung injury is a common complication of thoracic cancer radiotherapy.A lot of animal experiments and clinical studies have shown that ionizing radiation-induced lung injury is a complex process regulated by a variety of cytokines.The transcription factors including nuclear factor κB,MAPK and activator protein-1 are involved in radiation-induced lung injury by regulating the synthesis of a variety ofinflammatory proteins.The flavonoids play a role in radiological protection by blocking the pathway of nuclear factor kB and activator protein-1.