Evaluation on the cardiovascular safety ot AIDS patients with highly active antiretroviral therapy by echocardiography / 中国基层医药

ABSTRACT

Objective To explore the clinical value of echocardiography in evaluating the cardiovascular safety of drugs for AIDS patients treated by highly active antiretroviral therapy(HAART).Methods 45 HIV-infected patients accepted three times of echocardiography respectively before the treatment,and after 48 weeks of HAART and 96 weeks of HAART.All kinds of echocardiographic parameters were measured.Results There were statistically significant differences among baseline group pretreatment [V-LVOT( 115.0 ± 13.8 ) cm/s,EDT(166.8 ± 26.7) cm/s,E'(26.8±6.7)cm/s],48 weeks [V-LVOT( 113.0 ± 12.9)cm/s,EDT(172.9±31.0)cm/s,E'(23.8 ±5.0)cm/s] of HAART and96 weeks[V-LVOT(107.0±13.3)cm/s,EDT(140.4 ± 19.3)cm/s,E'(22.7±6.4)cm/s]of HAART for parameters of V-LVOT,EDT and E'( all P ＜ 0.05 ),other echocardiographic parameters showed no statistically significant differences(all P＞0.05).Conclusion Short-term of HAART was provided with cardiovascular safety,the invasive echocardiography could accurately evaluate the cardiac function and structure of AIDS patients with HAART.