Clinical observation of voriconazole prevention and cure on invasive fungal infection in patients with hematological malignancy / 中国医师进修杂志

ABSTRACT

ObjectiveTo study the therapeutic effect and safety of voriconazole prevention and cure on invasive fungal infection (IFI) in patients with hematological malignancy.MethodsSeventy-six patients with hematological malignancy were divided into observation group (39 cases) and control group (37 cases) by random digits table.The control group was given voriconazole of intravenous drip.The observation group was given voriconazole of intravenous drip sequence oral administration.The rates of occur IFI and adverse effect were compared between the two groups.ResultsIn observation group and control group,the confirmed diagnose rates were 17.9％(7/39) and 18.9％(7/37),clinical diagnose rates were 23.1％(9/39)and 27.0％ (10/37),para-diagnose rates were 59.0％(23/39) and 54.1％(20/37),there was no significant difference between the two groups(P＞ 0.05).In observation group and control group,the paropsia rates were 12.8％(5/39) and 21.6％(8/37),transaminase elevated rates were 12.8％(5/39) and 43.2％( 16/37),there were significant differences between the two groups(P ＜ 0.05 ).ConclusionThe voriconazole of intravenous drip sequence oral administration and intravenous drip has a nice effect to IFI,and intravenous drip sequence oral administration could reduce the adverse effect.