Association study of RANKL rs7984870 polymorphism and risk of rheumatoid arthritis / 中华微生物学和免疫学杂志
Chinese Journal of Microbiology and Immunology
;
(12): 1072-1075, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-428235
ABSTRACT
ObjectiveTo elucidate the association between RANKL rs7984870 C >G polymorphism and the susceptibility to rheumatoid arthritis in a Chinese Han population.MethodsGenotypes were determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) method in 214 rheumatoid arthritis cases and 478 controls.ResultsThe RANKL rs7984870 C>G genotype frequencies were 27.3% ( CC),51.2% ( CG),21.5% (GG) in the rheumatoid arthritis group and 25.3% (CC),49.1% (CG),25.7% (GG) in the control group respectively; Logistic regression analyses revealed that the risk associated with RANKL rs7984870 C>G variant genotype was 0.78 (95% CI =0.49-1.24) for RANKL rs7984870 GG compared with its wild-type homozygote.ConclusionRANKL rs7984870 polymorphism may not serve as a risk factor of rheumatoid arthritis susceptibility.Further functional studies are warranted to verify our findings.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
/
Risk factors
Language:
Chinese
Journal:
Chinese Journal of Microbiology and Immunology
Year:
2011
Type:
Article
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