The therapeutic effects of oxygen inhalation combined with relaxation training on generalized anxiety disorder / 中华物理医学与康复杂志

ABSTRACT

Objective To observe the therapeutic effects of oxygen inhalation combined with relaxation training on patients with generalized anxiety disorder (GAD).Methods A total of 188 GAD patients were divided into the study group and the control group randomly.The two groups were treated with conventional antianxiety drugs (paroxetine),in addition to conventional medical therapy.The study group was aided with oxygen inhalation and relaxation training,the control group was given benzodiazepine.The scores of Hamilton anxiety rating scale (HAMA),global improvement(GI) [ a part of clinical global impression (CGI) ],and treatment emergent symptom scale (TESS) were used to evaluate clinical effects and adverse reactions before and after 4-week treatment.The indexes of breathing,heart rate and blood pressure were evaluated before and after treatment.Results The scores of HAMA scale and GI in the two groups were significantly different after treatment( P ＜ 0.05 ),and the study group changed significantly( P ＜ 0.05 or P ＜ 0.01 ). The adverse reactions of the two groups were slight,there was no significant difference of TESS before and after treatment ( P ＞ 0.05 ). There was no significant difference in terms of breathing,heart rate and blood pressure between the two groups before treatment( P ＞ 0.05 ),but were all lower after treatment the study group changed more apparently and significantly(P ＜ 0.01 ).Conclusions Based on conventional drugs treatment oxygen inhalation combined with relaxation training could improve anxiety and somatization rapidly,there was no obvious adverse reaction and the patients compliance was good,so the treatment was worth to use in clinic.