Relationship between Survivin protein and esophageal cancer: a systematic review / 肿瘤研究与临床
Cancer Research and Clinic
;
(6): 34-37, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-428311
ABSTRACT
Objective To investigate Survivin protein and esophageal cancer with a systematic review.Methods The published studies were searched in the Cochrane Library (Issuel,2011),Pubmed and CNKI databases, and other relevant journals were also hand searched to identify all the relevant case-control trials.Then the quality of the included trials was assessed and meta-regression analysis was performed,by STATA 11.0 software.Results A total of 15 studies were recruited.As for the positive rate of Survivin expression, significant differences were tested between esophageal cancer vs.normal esophageal tissues (OR =39.98, 95 % CI =15.08-106.02, P < 0.05).No significant difference was tested between cell differentiation G3 vs.cell differentiation G1-G2(OR =1.47,95 % CI =0.59-3.68,P > 0.05).There were significant differences between T stagesⅢ-Ⅳ vs.T stages Ⅰ-Ⅱ (OR =2.82,95 % CI =1.35-5.90,P < 0.05),clinic stages Ⅲ-Ⅳ vs.clinic stages Ⅰ-Ⅱ (OR =2.99, 95 % CI =2.03-4.41, P < 0.05), lymph node metastasis vs.non-lymph node metastasis (OR =4.11,95 % CI =2.79-6.05,P < 0.05).Moreover,Survivin expression was positively correlated with the expression of hypoxia inducible factor-1α (HIF-1α) (r =0.542,P < 0.005).Conclusion Survivin expression increased malignant behaviors of esophageal cancer.There might be substantial correlations between Survivin and HIF-1α expression and esophageal cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
/
Systematic reviews
Language:
Chinese
Journal:
Cancer Research and Clinic
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS