Expression of nestin and Ki-67 in malignant peripheral nerve sheath tumors and its significance / 肿瘤研究与临床
Cancer Research and Clinic
;
(6): 246-249, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-428779
ABSTRACT
Objective To explore the expression of nestin and Ki-67 in malignant peripheral nerve sheath tumors (MPNST) and its significance in the differential diagnosis. Methods Immunohistochemical technique (SP) was used to detect the expression of nestin and Ki-67 in 42 cases of MPNST and 24 cases of benign peripheral nerve tumor.Results Total expression of nestin was found in 95.2 %(40/42) of MPNST.Strong expression of nestin was detected more frequent in MPNST compared to benign peripheral nerve tumors [40.5 %(17/42) versus 4.2 %(1/24),x2 =8.403,P =0.004].Ki-67 labeling index in MPNST varied from 1%-70 %.However,greater than 3 % labeling index of Ki-67 staining was observed in 64.3 %(27 / 42) of MPNST while none of the 24 benign tumors had nuclear staining exceeding 3 %. The higher Ki-67 labeling index showed significant differences between the two groups (x2 =23.518,P =0.000).Conclusion Nestin and Ki-67 are useful markers in distinguishing MPNST from benign tumors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Cancer Research and Clinic
Year:
2012
Type:
Article
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