Relationship of Survivin and Caspase-3 protein in ovarian serous tumors and their clinical signifficance / 肿瘤研究与临床
Cancer Research and Clinic
;
(6): 308-310, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-428857
ABSTRACT
Objective To investgate the expression of Survivin and Caspase-3 in primary ovarian carcinoma, and to explore their relationship. Methods The expression of Survivin and Caspase-3 was detected by flow cytometry (FCM) . Results FCM showed that the expression of Survivin in ovarian serous carcinoma was higher than that in serous cystadenoma and normal ovarian tissues (F=19.80;P=0.00) and correlated with the clinical stage( t=2.882,P=0.009).The expression of Caspase-3 in ovarian serous carcinoma was higher than that in serous cystadenoma and normal ovarian tissues (F=16.32,P=0.00)and has no correlativity with clinical stage,histological grade,and lymph metastasis(P>0.05).Survivin expression was negatively correlated with Caspase-3 expression in ovarian serous tumors (r=0.43,P=0.029).Conclusion Survivin was negatively correlated with Caspase-3 in ovarian serous tumors.Combination of detecting the two protein expressions might be valuable in diagnosis and determining the malignant degree in ovarian serous carcinoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Cancer Research and Clinic
Year:
2012
Type:
Article
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