Study on allergic reactions due to tubecular treatment medications for tubecular patients at the national hospital of tuberculosis and lung diseases (1998-2003)

ABSTRACT

Tuberculosis treatment-related allergic reactions are increasing. It influenced to therapy regimen for tubeculosis over our country. Objectives: (1) Make a list of tuberculosis treatments can cause allergic reactions. (2) Study on clinical symptoms of tuberculosis treatment allergy in tubeculosis patients. (3) Study on some of liver biochemical test. Subjects and method: 91 patients who had allergic reactions related to tuberculosis treatments presented between 1998 and 2003 in the National Hospital of Tubeculosis and Lung Diseases. Cross sectional survey and retrospective study. Results: There are 6 tuberculosis treatments related to allergic reactions rifampicin, streptomycin, ethambutol, isoniazid, pyrazynamid and RH; Rifampicin, streptomycin and ethambutol are main cause. Most of all allergic reations happened late (after 24 hours) in patients with lung tuberculosis treated by "formula I". Out of 7 signs of allergic reaction, 3 clinical symptoms happened most are erythema, prurigo and fever. Delayed type of allergy is main part. Erythema is the main clinical form. There were no changes in AST, ALT and total bilirubin on blood test. Conclusion: Tuberculosis treatment of "formula I" are main cause of allergic reactions with various clinical symptoms and it can damage liver cells.