Immunohistochemical Demonstration of Nerve Fibers of the Human Knee Synovium / 대한정형외과연구학회지
Journal of Korean Orthopaedic Research Society
;
: 10-15, 2007.
Article
in Korean
| WPRIM
| ID: wpr-42900
ABSTRACT
PURPOSE:
To demonstrate the presence of nerve fibers including nociceptive fibers in synovium of human knee joint using immunohistochemistry. MATERIALS ANDMETHODS:
10 Synovial membrane tissues of knee joint obtained from 5 cadavers were analyzed immunohistochemically using antibodies to protein gene product 9.5, betaIII-tubulin, substance P and calcitonin gene-related peptide (CGRP).RESULTS:
Many nerve fibers immunoreactive for protein gene product 9.5 and betaIII-tubulin were demonstrated in synovial folds of human knee joints. Also, immunostaining showed the presence of free nerve ending fibers immunoreactive for substance P and calcitonin gene-related peptide in synovium.CONCLUSION:
The presence of putative nerve fibers including nociceptive fibers in synovial folds supports a possible role for theses structures as source of knee joint pain.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Synovial Membrane
/
Cadaver
/
Immunohistochemistry
/
Substance P
/
Calcitonin Gene-Related Peptide
/
Knee
/
Knee Joint
/
Antibodies
/
Nerve Endings
/
Nerve Fibers
Limits:
Humans
Language:
Korean
Journal:
Journal of Korean Orthopaedic Research Society
Year:
2007
Type:
Article
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