The research on the immuno-modulatory abilities of myelodysplastic syndromes patients bone marrow derived mesenchymal stem cells / 中华微生物学和免疫学杂志
Chinese Journal of Microbiology and Immunology
;
(12): 449-454, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-429118
ABSTRACT
Objective To investigate that whether the immuno-modulatory capacity is intact in myelodysplastic syndrome-refractory anemia (MDS-RA) derived mesenchymal stem cell (MSCs) and what are the differences compare with those from normal donors.Methods Isolating MSC from MDS and normal donors respectively and exam their differences on T lymphocyte activation,proliferation and suppression.Results The results showed that the capacity of suppressing T cell proliferation and activation is weakened.Conclusion We propose that MSCs from pathological environment might be abnormal and should not be used for autologous transplantation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Microbiology and Immunology
Year:
2012
Type:
Article
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