The role of calcium in the rVvhA induced THP-1 cells apoptosis / 中华微生物学和免疫学杂志
Chinese Journal of Microbiology and Immunology
; (12): 512-518, 2012.
Article
in Zh
| WPRIM
| ID: wpr-429150
Responsible library:
WPRO
ABSTRACT
Objective To study the role of Vibrio vulnificus cytolysin(rVvhA) induced THP-1 apoptosis and calcium influx.Methods CCK-8 cell proliferation kit,Fluo3/AM staining and AnnexinV/PI staining were performed to identify the apoptosis and calcium influx induced by rVvhA in THP-1 cells.Results rVvhA could induce THP-1 apoptosis and up-regulate the cellular calcium concentration.BAPTAAM could enhance the calcium influx induced by rVvhA in THP-1.Conclusion rVvhA had cytotoxic to THP-1 cells by inducing apoptosis and triggering extracellular calcium influx.
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WPRIM
Language:
Zh
Journal:
Chinese Journal of Microbiology and Immunology
Year:
2012
Type:
Article