Immunotherapy of type 1 diabetes:current state and prospects / 国际儿科学杂志

ABSTRACT

In type 1 diabetes,insulin producing pancreatic β-cells are attacked and destroyed by autoreactive T cells,which causes major impairments of blood glucose metabolism and finally development of lifethreatening complications.Many immunosuppressive and immunoregulatory therapies have been and are currently being evaluated for their utility in the prevention and treatment of type 1 diabetes.Agents for intervention are generally classified according to their antigen-speeificity (antigen-specific and nonantigen-specific) and β cell growth or anti-apoptotic agents.Combination of these agents from different class would minimize toxicities and realize synergies to enhance and prolong efficacy.