Effect of Fentanyl on the Action Duration of Vecuronium under the General Anesthesia Using Enflurane-N2O / 대한마취과학회지

ABSTRACT

To evaluate the interaction between fentanyl and vecuronium, I have studied the recovery of train-of-four(TOF) responses after administration of vecwonium in 40 patients under enflurane-N2O inhalational anesthesia. Patients were allocated randomly to 2 groups of 20 patients each to receive 3 ug/kg fentanyl(fentanyl group) and normal saline of same volume (control group) 10 min before administration of 0.1 mg/kg vecuronium. The times from initial administration of vecuronium to the first appearances of Tl, T2, T3, and T4 differed significantly between groups (p<0.01) 15.8+/-6.5 min, 21.4+/-7.2 min, 25.1+/-8.2 min, and 27.9+/-8.7 min in the control group, and 22.7+/-5.1 min, 28.4+/-5.3 min, 31.9+/-5.9 min, and 34.7+/-6.7 min in the fentanyl group, respectively. However, the T2-T4 recovery index did not differ significantly between groups 5.9+/-3.1 min in the control group, and 6.3+/-3.0 min in the fentanyl group. It is concluded that fentanyl can slightly prolong the action duration of vecuronium, but not affect it during the recovery from muscle relaxation.