Research progress on microRNA polymorphisms and susceptibility of tumor / 肿瘤研究与临床

ABSTRACT

MicroRNA (miRNA) is a class of micro,endogenously-initiated non-coding RNA that negatively regulate gene expression at the post-transcriptional level and involved in tumorigenesis.Polymorphisms in miRNA sequences (miRSNP) alter mature miRNA levels and target mRNA selection.Recent findings have demonstrated that miRSNP mediated epigenetic alteration of miRNA can be one of the mechanism in tumor progression and may play critical role of hallmarks in cancer susceptibility.This review described the most recent advances in the field of hot miRSNP and susceptibility of tumour.