mTOR and glomerular disease / 国际儿科学杂志

ABSTRACT

The mammalian target of rapamycin (mTOR)is a evolutionary conserved serine/threonine kinase that catalytics specific substrates and regulates cellular basic physiological events,such as growth,proliferation,autophagy and protein translation.It plays an important role in the regulation of cancer,diabetes and a variety of kidney diseases.Most of glomerular diseases are resulted from the podocytes and filtration barrier damage.Studies have suggested that there is a close relationship between mTOR and podosytes damage,but specific mechanism of regulation is not clear now.This review discusses the regulatory mechanism of mTOR kinase and its role in the glomerular disease to provide new ideas for understanding of glomerular disease pathogenesis.