Study on the correlation between the levels of HbA1c,plasma NT-proBNP and the cardiac function in patient with acute coronary syndrome / 中国基层医药

ABSTRACT

Objective To investigate the correlation between glycosylated hemoglobin(HbAlc),plasma NTproBNP and the cardiac function in patients with acute coronary syndrome(ACS).Methods 53 patients with both ACS and type 2 diabetes mellitus(T2DM)(T2DM group),67 patients with ACS(ACS group)were selected as the objects.The HbAlc level was detected by immunohistochemical than turbidimetry,and the content of NT-proBNP was detected by electrochemiluminescence method.Results The levels of HbAlc,plasma NT-proBNP of the T2DM group were(9.21±1.23)％,(3.56±1.12)ng/ml,respectively,which were higher than those of ACS group[(5.09±0.67)％,(0.14±0.04)ng/ml](t=6.495,9.277,all P＜0.01);The cardiac function of ACS patients was positively correlated with the levels of HbA1c and plasma NT-proBNP(r=0.517,0.589,all P＜0.01),and there was positive correlation between the levels of HbAlc and plasma NT-proBNP in ACS patients(r=0.431,P＜0.05).Conclusion The HbAlc and NT-proBNP can promote the injury of the cardiac function of ACS patients,and can be used as diagnostic indicators of the injury of the cardiac function of ACS patients.