The influence of edaravone on serum ET,slCAM-1,MCP-1 and neurological function in acute cerebral infarction / 中国基层医药

ABSTRACT

Objective To explore the influence of edaravone on serum endothelin(ET),soluble intercellular adhesion moleculel(sICAM-I)and monocyte chemotactic factor 1(MCP-1)and neurological function in acute cerebral infarction patients.Methods 90 patients with acute cerebral infarction were randomly divided into treatment group(additional edaravone)and control group(routine treatment).The serum levels of ET,sICAM-1 and MCP-1were detected by ELESA pretherapy and after treatment.Neurological functional deficit scores(NDS)was utilized for assessment pretherapy and after treatment.Results The levels of serum ET,sICAM-1 and MCP-1 in acute cerebral infarction groups were significantly higher than those of control group(t=4.55,4.62,4.75,4.43,4.61,4.73,all P＜0.05);The levels of serum ET,sICAM-1 and MCP-1,NDS in both two groups after treatment were significantly lower than those before treatment(t=4.12,4.23,4.15,3.91,3.92,3.83,4.52,4.36,all P＜0.05),and the levels of serum ET,sICAM-1,MCP-1 and NDS in the treatment group were significantly lower than those in the control group(t=3.72,3.63,3.53,3.72,all P＜0.05).Conclusion Edaravone can decrease the levels of ET,sICAM-1 and MCP-1in acute cerebral infarction patients.It can lighten acute inflammation and brain injury,protect the tissue of brain.